NCAPG2 peptides: A novel cancer therapeutic agent

Successful cell division depends on the proper attachment of microtubules to the kinetochore of each chromosome. NCAPG2, a component of condensin II Complex, aids in this process by recruiting protein polo-like kinase 1 (or PLK1) to the kinetochore. Proper localization of PLK1 to the kinetochore prevents cell division from proceeding until each kinetochore is properly attached to a microtubule. Thus, in the absence of NCAPG2-PLK1 binding, abnormal cell division may occur before all chromosomes are properly attached, resulting in chromosomal defects that can halt cell division altogether. For more information, please click here.

Successful cell division depends on the proper attachment of microtubules to the kinetochore of each chromosome. NCAPG2, a component of condensin II Complex, aids in this process by recruiting protein polo-like kinase 1 (or PLK1) to the kinetochore. Proper localization of PLK1 to the kinetochore prevents cell division from proceeding until each kinetochore is properly attached to a microtubule. Thus, in the absence of NCAPG2-PLK1 binding, abnormal cell division may occur before all chromosomes are properly attached, resulting in chromosomal defects that can halt cell division altogether. For more information, please click here.