A pharmaceutical composition for inhibiting cancer metastasis using regulation of BIGH3

Item Number: 548
Industry: Therapeutic
Category: Oncology
Development Stage: Early Stage
Organisation Type: University
Country: South Korea
Business Opportunity: Out-Licensing, Technology Transfer, Collaboration R&D


We report that lithium inhibits colon cancer metastasis by blocking lymphangiogenesis. Lithium reduces the expression of transforming growth factor-β-induced protein (TGFBIp) in colon cancer cells by inhibiting Smad3 phosphorylation via GSK3β inactivation. Moreover, lithium inhibits lymphatic endothelial cell migration, which is increased upon TGFBIp expression in tumor cells.

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